Migraines happen and I still find the pain happens for no known cause. There is a difference, however, because whatever is not known there is still different with what is not known about my diagnosis. The difference is known. If that is not good enough then to search for a cure seems like a quest.
Some acts of the quest carry a virtue of magic truth, which is still true even without magic acts. A meditation at a shrine of truth may have related to an event of migraines, for example.
Expand from that; example: Doctors shrink. Scientists grow.