And falls dangerously into information on self medication. Any questions regarding dosage and frequency or timing of medication should be obtained from your doctor based upon your personal medical profile. All you have to do is ask this question of your Dr. and you will get answers that are legitimate to your personal needs. And as Cassie stated, follow the directions on the label, it will tell you to take X pills a day which generally means all at once, or X pills twice a day. If this information is not on the medication label, try filling your perscription at a legitimate pharmacy.