Author Topic: New article about how prenatal hormones determine the sex of the brain  (Read 1545 times)

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Offline HughE

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A website called Hormones Matter have just published this article on my behalf:

https://www.hormonesmatter.com/synthetic-hormones-pregnancy-gendered-brain-development/

In it, I talk about the discovery 60 years ago that
a) the brain has a sex that arises during prenatal development and, once set, remains like that for life
and
b) the sex of the brain is determined by hormone levels during prenatal development, not by genetics.

The discovery became known as the organizational-activational hypothesis. I found a pair of slides illustrating one of the early experiments used to demonstrate it, involving manipulating hormone levels during the critical period for rat brain development (through castration or by injecting testosterone). Basically, what those experiments show is that you can produce male rats with female brains through castration at the appropriate time, or females with male brains. Similar experiments with similar results have been carried out on numerous other animal species, including Rhesus monkeys, which are one of the closest animal models to human beings.

Unfortunately, news of that discovery never filtered through to the world of medicine, where doctors have been giving pregnant women synthetic female hormones (estrogens and progestins) ever since WW2 ended, for miscarriage prevention and for various other medical reasons. In adult men, these drugs act as chemical castration agents, and the way they're administered causes the foetus to be exposed during the critical period for sex differences in the brain. Therefore you'd expect them to be producing male bodied people with female brains, which is certainly what seems to have happened with the earliest of them, the artificial estrogen DES. DES is no longer used, however I think there's a very real possibility it could be happening with the drugs that replaced DES, since they also are artificial female hormones, and also have testosterone suppressive properties in adult men.

Online zirconia

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This was fascinating. Thank you...

Offline Nphrom

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I want to post here. There might be a better place but I joined this group to share this and this is almost a similar subject. My mother once told me I was born, "with milk in my breast". This is a rare phenomenon. I have found very little information about it online. It is colloquially called "witch's milk". There's a scientific name for it. When babies are born with witch's milk it is removed with a syringe. I could probably tell you which side it was on by the side that has had the more pronounced gynecomastia? not sure how to spell it. I have a theory that I am cross gendered because that milk is a strong solution of female hormones and as a newborn I was overwhelmed by it. Sounds a little lame putting it in writing. Does anyone have information on witch's milk. This is the first time I posted here or any similar forum so thank you for having me. Look forward to sharing more in the future of my life and experiences.

Online Northern Star Girl

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I want to post here. There might be a better place but I joined this group to share this and this is almost a similar subject. My mother once told me I was born, "with milk in my breast". This is a rare phenomenon. I have found very little information about it online. It is colloquially called "witch's milk". There's a scientific name for it. When babies are born with witch's milk it is removed with a syringe. I could probably tell you which side it was on by the side that has had the more pronounced gynecomastia? not sure how to spell it. I have a theory that I am cross gendered because that milk is a strong solution of female hormones and as a newborn I was overwhelmed by it. Sounds a little lame putting it in writing. Does anyone have information on witch's milk. This is the first time I posted here or any similar forum so thank you for having me. Look forward to sharing more in the future of my life and experiences.

@Nphrom
Dear Nphrom
    You have a lot of good thoughts and questions in your first post here...  other members here will chime in and offer their thoughts regarding the issues that you shared.
    Please know that I am not trying to hijack your post and your questions and concerns but first I wish to Officially Welcome YOU to Susan's Place.
    I am happy to see that you have signed up as a member of Susan's Place and have submitted your first posting. 

    As you post here on the forums you will be able to exchange thoughts and comments with others that are experiencing many of the same things that you wrote about.
 
    This is the right place for you to be to find out what others may have to say that may have been in your circumstances and with your questions and concerns.
    There are a lot of members here that will be able to identify with your situation as you continue to feel free to share it.
 
    I want to warmly WELCOME you to Susan's Place
You will find this a safe and friendly place to share with others and to read about others similar trials, tribulations, and successes.

    As you are certainly aware you can share with others and involve yourself with some give and take with other like-minded members.  When frustrated or if you have successes you can share it here if you wish and receive support from others and offer support to others. ....
     ***There is a very good chance that you might find that you will make some new like-minded friends here. 

    Please come in and continue to be involved at your own pace.   Other members will be along shortly to give you their thoughts about your questions and concerns that you mentioned in your very first posting.
   
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Please look closely at the LINKS in RED, answers are there to many questions that new members ask....

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Here are some links to the site rules and stuff that all new members should be familiar with:
 
Things that you should read
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Started HRT:   March 2015
Went Full-Time    December 2016
Quit my male-mode job and relocated to a very small town in Alaska in January 2017
I'm a blonde, blue eyed woman, Age 40

Online Northern Star Girl

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@Nphrom
Dear Nphrom:

If you feel so inclined please feel free to stop by the Introductions Forum to tell more members about yourself!
 
With more exposure to more members here you will be able to get more responses to your questions and concerns.

Wishing your well as you continue to be involved in the forums.

NOTE: Now, after all of this Greeting and Welcoming stuff, I will give you and everyone the thread back so you can get some answers from other members.

Again, Welcome to Susan's Place.
Danielle
***SEE MY LINKS BELOW
The Ramblings of a Northern*Star Girl
A New Chapter: ALASKAN DANIELLE's Chronicles
I am the HUNTED PREY: Danielle’s Chronicles
Things change re: ALASKAN DANIELLE
Positive Mindset... put away negativity

Started HRT:   March 2015
Went Full-Time    December 2016
Quit my male-mode job and relocated to a very small town in Alaska in January 2017
I'm a blonde, blue eyed woman, Age 40

Offline Rakel

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... Therefore you'd expect them to be producing male bodied people with female brains, which is certainly what seems to have happened with the earliest of them, the artificial estrogen DES. DES is no longer used, however I think there's a very real possibility it could be happening with the drugs that replaced DES, since they also are artificial female hormones, and also have testosterone suppressive properties in adult men.

DES was commonly given to pregnant women just after WW II.  In fact male babies born from 1947 to 1955, who know that their mothers took DES during pregnancy, have shown almost a 40% incidence of gender related issues. There are many more of us who do not know what their mother's medical history was, but we have to wonder what is the real overall rate of gender issues of any kind for people who were exposed to DES in the womb?

Since DES was not used since the 1970's, this does not explain the current situation for people with gender issues, but we do need to be aware of the consequences of environmental exposure.



Offline jaysonderulo

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this is interesting, did not know thsi at all!

Offline natasha

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I was born in 64 near Toronto Canada. From what I have found, DES was in very common use in that area. My mom had a miscarriage before me, and was obviously very worried about it happening again. My Dad has told me that she was on several medications during her pregnancy with me. Interestingly enough she also made it known to my dad that she was upset in having a "boy".  She turned out to be a pill popping drunk and I was pretty much brought up by my Dad. 

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