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Hormones and Epilepsy

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Jade Alice:
Hi there. I am a 20 year old pre-transition mtf. I am in the process of being cleared for HRT by my therapist. I wanted to ask if anyone has or has known any other trans girls going on HRT while taking seizure medications. I am on two seizure meds valproic acid and carbamazapine. From my own research these medications can have moderate to severe interactions with estradiol. I haven't had a seizure in 10 years now since beginning the meds. I know these are mainly questions for Drs, but figure might as well ask if anyone has gone through something similar and what the results were. Thank you!

Northern Star Girl:

--- Quote from: Jade Alice on February 05, 2020, 05:47:52 pm ---Hi there. I am a 20 year old pre-transition mtf. I am in the process of being cleared for HRT by my therapist. I wanted to ask if anyone has or has known any other trans girls going on HRT while taking seizure medications. I am on two seizure meds valproic acid and carbamazapine. From my own research these medications can have moderate to severe interactions with estradiol. I haven't had a seizure in 10 years now since beginning the meds. I know these are mainly questions for Drs, but figure might as well ask if anyone has gone through something similar and what the results were. Thank you!

--- End quote ---
@Jade Alice
Dear Jade
    Thank you for submitting your very first post here on the Forums.   Please know that I am not ignoring your important information seeking questions but But, FIRST THINGS FIRST, I need to Officially Welcome You and give you important rules and information about the Susan's Place Forums.
   
    As you post here on the forums you will be able to exchange thoughts and comments with others that are experiencing many of the same things that you wrote about.
 
    This is the right place for you to be to find out what others may have to say that may have been in your circumstances and with your questions and concerns.
    There are a lot of members here that will be able to identify with your situation as you continue to feel free to share it.
 
    I also want to warmly WELCOME you to Susan's Place. 
You will find this a safe and friendly place to share with others and to read about others similar trials, tribulations, and successes.

    As you are certainly aware you can share with others and involve yourself with some give and take with other like-minded members.  When frustrated or if you have successes you can share it here if you wish and receive support from others and offer support to others. ....
     ***There is a very good chance that you might find that you will make some new like-minded friends here. 

    Please come in and continue to be involved at your own pace.   Other members will be along shortly to give you their thoughts about your questions and concerns that you mentioned in your very first posting.
   
    There is information and important LINKS that I have included below.   You will find information about the site that will help you navigate around and best utilize the features here.   
Please look closely at the LINKS in RED, answers are there to many questions that new members ask....

Again, Welcome to Susan's Place.
Danielle

Here are some links to the site rules and stuff that all new members should be familiar with:
 
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Northern Star Girl:
@Jade Alice
Dear Jade Alice:

Please feel free to stop by the Introductions Forum to tell more members about yourself!
 
With more exposure to more members here you will be able to get more responses to your questions and concerns.

Wishing your well as you continue to be involved in the forums.

NOTE: Now, after all of this Greeting and Welcoming stuff, I will give you and your readers your thread back so you can get some answers from other members.

Again, Welcome to Susan's Place.
Danielle

NOTE:  Now that all of this Greeting and Welcoming stuff is done, I will let you and others have this thread back so your can continue your conversation and hopefully get the answers you are seeking.

Rakel:

--- Quote from: Jade Alice on February 05, 2020, 05:47:52 pm ---Hi there. I am a 20 year old pre-transition mtf. I am in the process of being cleared for HRT by my therapist. I wanted to ask if anyone has or has known any other trans girls going on HRT while taking seizure medications. I am on two seizure meds valproic acid and carbamazapine. From my own research these medications can have moderate to severe interactions with estradiol. I haven't had a seizure in 10 years now since beginning the meds. I know these are mainly questions for Drs, but figure might as well ask if anyone has gone through something similar and what the results were. Thank you!

--- End quote ---

Good evening Jade,

Your question about drug interaction is typically answered by Pharmacists, which I have been for over 40 years, now retired.

Both your seizure medications interact with Estradiol.

Carbamazepine increases liver enzymes making the Estradiol less effective. This can be mitigated by using Estradiol patches , injection or sublingual methods. These routes of administration avoid the first pass through the liver, making the Estradiol last a bit longer.

The same thing happens with the Valproic Acid, this time it is the Estradiol that increases the elimination of the Valproic Acid, making your Valproic Acid blood levels lower. If this happens, your seizures could return.

Either way, if your doctor closely monitors your medication blood levels, you may be able to take HRT successfully.

Jade Alice:

--- Quote from: Northern Star Girl on February 05, 2020, 05:54:51 pm ---@Jade Alice
Dear Jade Alice:

Please feel free to stop by the Introductions Forum to tell more members about yourself!
 
With more exposure to more members here you will be able to get more responses to your questions and concerns.

Wishing your well as you continue to be involved in the forums.

NOTE: Now, after all of this Greeting and Welcoming stuff, I will give you and your readers your thread back so you can get some answers from other members.

Again, Welcome to Susan's Place.
Danielle

NOTE:  Now that all of this Greeting and Welcoming stuff is done, I will let you and others have this thread back so your can continue your conversation and hopefully get the answers you are seeking.

--- End quote ---
Thank you 😊

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