I thought it prudent to post this here. One of the biggest games of the current generation, Cyberpunk 2077, recently changed its character creation to allow players to create any kind of player character they like.
Here's a
link to an article explaining why they did what they did.
It hasn't gone down well. Because... well... gamerz are gamerz, and the slightest little thing will make them want to break their mom's crockery and come out of the basement to the bright light of day, just to rage about stuff that doesn't apply to them. But yeah... I thought it was worth mentioning. If you're looking for a game where... to use their term... "transhumanism" is a big thing in both the lore and the gameplay, then you could do much worse.

I already have my pre-order in.
