Somewhat... your body is doing a lot stuff internally. Building, changing, etc. Have you had your B12 levels checked? A B12 supplement in the form of methylcobalamin may be helpful. I find that eating the right stuff (plenty of fruits, vegetables, and lean protein) is the most effective at combating fatigue. Also getting plenty of sleep 7-8 hours per night also works wonders. I still get tired much faster now than pre-HRT, but diet, rest, and exercise are now much more important to me.