they are both intersex conditions. i discovered before hrt that i had symptoms alot like both of these, but the difference is that klinefelters is involving sex chromosomes while 5 alpha reductase deficiency involves the inability for testosterone to properly bind into dihydrotestosterone resulting in reduced masculinization during puberty, and some more feminizing. my voice never went down to a male pitch, i had partial breast development, lots of female fat distribution, soft feminine bone structure, poor muscle strength. even though i was almost 18 by the time of hrt, i had about tanner stage four or five as far as pubic hair. the only thing really was excessive hair for a female. so, are the conditions closely related as far as symptoms? the early symptoms for 5ARD are basically across the board while klinefelters can't really be determined unless it's a chromosomal karyotype, which i've had done, but i am only XY. i'm asking this more out of curiousity than anything. since i'm on a female hormone balance now, it is basically being cured.
