Orals are broken down by the liver, which degrades the estrogen so not alot of the dosage is even absorbed. I have always kept my hormone dr in check, as he does not know as much as I would like ha ha! I started off with oral, but quickly moved to inject able, as all of the hormone gets into the bloodstream and promotes a quicker change in most people. Alot also depends on your genetic disposition, but proper dosaging and what method of delivering is key. With spironolactone, I have only used the oral, because it works good enough like that and is just a DHT blocker. You are 21, so you should see a good change in 4-5 months, and will continue getting better results. 2wiks is just too soon to see much of any changes other than the hot flushes perhaps some moods swings.