Mine is twice daily. I take my thyroid an hour before eating and the rest of the pills in the morning. If your on thyroid, estradiol or the other estrogens will not work as well if taken together. My doses may be reduced or eliminated soon. I got a potentally hazardous condition that is being diagnosed. HRT usage and thyroid along with a dozen other things are indicated as cause. However, this condition has been going on for 15 years in a milder state mimicking another harmless condition. I got an appointment with a specialist next week.
My T level is currently 124 ng./dl as of Wednesday. My Dr. said it is still low despite taking a full dosage. But high for a woman. My liver, kidney, potassium are OK.
Joelene