I'm really picky and conscious about my pants.
As I have very wide hips, and very...luscious thighs...and a booty (Oh heavens, what a booty)
But anyway, Skinnys would never be doing me any favors, I only wish that I had the figure to wear them.
I do know that some men (Including FtMs) can pull them off very well,
It depends on body type, of course, not to mention on style as well

But for me, it all comes down to comfort.
If they feel good, wear those suckers until they wear out in your sleep.