First off, I'm not against smokers... The only smokers I'm against are the ones who consider everywhere their ashtray and butt trash can.
With that said, I'd stop smoking or at least highly cut back while on HRT. Personally, I'd quit all together. My mom's body decided to not wake up on Christmas Day 2013 with tobacco being high contributor. I pulled the plug & oxygen 2 days later. 55 is pretty darn young to die.
Christmas around noon:
"Hey, come to the hospital to see mom, she is probably not going to make it past tonight."
"Hey, your aunt is dying, better come see her now."
"Umm, your daughter is dying so you might want to fly 1400 miles to see her. Now."
"Your sister is dying, you should come to the hospital."
Yea, it kills the Christmas mood when family & extended family and their kids and spouses are piled into awaiting room 10:30 at night and all 80 people are allowed to stay after hours "given the situation" while their loved one may not survive the night.
Just a little perspective.