I'm not really a 'gamer', but I did get quite into Second Life for a while around 06/07.
It was quite an interesting experience from a gender perspective and kind of taught me that if it was physically possible for me to be 'stealth' as female in real life I would probably have issues.
I signed up with a female avatar and found everyone just completely accepted me as female, and I liked that a lot. It was quite a learning experience interacting with people as female without any physical constraints to hold me back (and I don't mean that from a virtual nooky perspective).
I made lots of friends, but, over time, I became good friends (platonically) with a lady there and we used to hang out and chat about everything real and virtual and she used to tell me some quite personal female specific things.
I found though that as much as I was happy, I was also feeling uncomfortable. It didn't feel quite like a proper friendship because I hadn't been fully open about myself. I felt it was unfair to her not to tell her and I felt bad about it. It was like I was being deceptive; which just isn't me.
So, I eventually told her everything. She was very shocked and actually thought I was joking at first... and said she'd never have guessed I was going to tell her that in a million years (as you can probably tell I was flattered!).
She was fine about it and we stayed as good friends as we had been before. Though it did very subtly change the dynamics.
I felt sad that I lost being completely accepted as female by telling her, but happy that I did the right thing and that it was then an honest friendship.
It taught me that even if I could do stealth (impossible from a physical and life point perspective anyway), that I'm too honest to do that and wouldn't be happy hiding part of who I am away.
So, yes... I guess you can learn things from Second Life...