Hey there everyone,
I read and concluded the relationships in the comic as Cassie did. I don't really believe that this has anything to do with transsexualism or any pokes at trans folk. I think that it would be the kind of comment that any siblings would throw at each other. There is no mention of transsexuals, gender, ftm, mtf. At my son-in-laws stag his best men dressed him as a woman, in slutty cloths, and paraded him around the club all night. They didn't mean to offend anyone, and neither did my son-in-law, it was just fun. In both cases I was not offended.
Just my thoughts,
Steph