Hi Stacey I have been on Estradiol for 1 1/2 months the changes that I'm going through my nipples an areolas are getting a lot lager an puffy and my breasts are getting larger (I have a IS condition I had small breast since puberty) My nipples an areolas are very sore , body hair takes longer to grow back, body oder is changing an my butt looks like is getting a tiny bit bigger, My skin is getting softer I can't lift heavy things like I did before. My thoughts an emotions are more female, That is about the changes I have seen so far..