Hmmmm, I'm on a low dose of spiro and take it 2x a day. My morning dose I never take with food though the label says too, because I'm never hungry in the morning either? And I never get upset stomach or anything n figured it works cuz I noticed the effects start at week two. However, knowing now its increased with food I'll now make it a point myself, to eat in the morning with it. Awesome post!