The best friend I have known for 20 or so years said he knew something was different about me. Mannerisms, style of dress, certain interests, mostly he noticed my attitude change when I finally figured it out. It made me happy knowing that and he being completely cool with my decision. He still is very supportive. All of my other friends are also very supportive.
On the other hand, my mother, I thought, was dropping hints about something different about me to other boys. My brother being gay, I figured she meant that. Sometime later due to completely unforeseen events, I came out to my mom (I left some clothes out, underwear in particular lol). She had no idea and was rather upset to say the least. She still refuses to talk about my transition and makes me out to be some super masculine son off hers. My brother reacted even worse (hostile perhaps) even though I thought he would have been more open. We are definitely not close anymore, if we ever really were.
In any case, hang onto those who make your life a treasure and leave behind those you don't need if you can.