Sara,
I've been following this thread and assuming that someone would state the obvious, but it hasn't happened yet. So, here goes. And please don't think this in any way judgmental. Like everyone else here, I just want to help.
Despite the title of this thread, your problem is neither the estrogen nor the mood swings. Even if the E is doing something new, that's not the root issue.
Your problem is the cocktail of substances you are taking in the interest of self-medication to "treat" your deeper issues. You've got drug interactions happening here that are likely very dangerous. And while I'm disturbed and saddened to hear that you had to go to the ER, I'm also relieved. You need serious conversation with someone who can help you before you go over the edge.
You also need to stop self-medicating -- which includes the recreationals -- until you can get a handle on things. This is serious stuff, and your life is at stake.
If any of those drugs you listed are prescriptions, you need to get yourself back to the prescribing physician and come clean about everything you are taking. Only then can you begin the hard work of figuring out which drugs, if any, are right for your situation.
This probably sounds harsh, and I don't mean it to, but you're playing with fire here, and we've all heard too many stories about people who were trying to figure out such complicated things on their own and wound up in some very bad places -- both physically and emotionally.
I really do wish you the best.
Lora