I'm on Androgen-Blockers - Nicotine/cigarette contraindication!!?

[Terracotta]

I'm a fit and healthy twenty one year old. With my one thing being a cigarette smoker, I've been able to quit cigarettes but not nicotine replacement!

I'm commencing androgen-blockers (spironactalone) before I commence estrogen

With my GID I was too depressed and anxious to possibly give up nicotine/smoking,
If I carry on my quit smoking nicotine lozenge routine over with starting spiro is this
a major contraindication?! 

I kind of figured the whole nicotine without damaging lungs thing to be less dangerous but I'm aware
that quitting smoking is very important with starting HRT but what about nicotine just by itself
Is it the nicotine or the physical act of burning smoke?

[KayXo]

All I know is that nicotine interferes with estrogen metabolism when taken orally because it induces (increases) those enzymes in the digestive tract (and liver, I think) that metabolize estrogen, therefore reducing the concentration of estradiol in the blood, by a lot! In one study, those who smoked had 5 times less the concentrations of those who didn't, when on oral estrogen (not transdermal).

Good luck on quitting smoking, I know how hard it is, being a former smoker and my mom is on the patch too, as we speak. I also quit when I started HRT.

[LittleEmily24]

According to my endo, he advised I stop smoking as well as stop ingesting nicotine in any way because the combination of the nicotine itself with the hormone pills can cause an increase in blood clots (among other things), but blood clots is enough for me to stop lol, Blood clots suck.

[kira21 ♡♡♡]

What KayXo says is true, but I would add that the contraindication actually comes from the clotting factor. Smoking increases your risk of DVT and estrogen tablets do also, so they consider them to be too much risk combined. Though studies show that the patch and transdermal administration does not suffer from the same risk factors, you will probably find that most endos consider smoking a contraindication anyway. Also, considering it negatively effects feminisation then you probably want to stop anyway.