There is no best method as long as your body gets the proper dosage of hormones.
Jenny and I slightly disagree here, but not too passionately, I want subdermal implants as well... just not on my current budget.
Also, Cindy and Jenny are among our very best posters here, so you are really meeting the family today!
Things that really matter most are, are you allergic? If not, can you afford it?
I am most interested in slow release hormones like shots, patches and implants, since they allow hormones to slowly cycle, which seems more like a natal female. Pills and topicals cycle too, just more rapidly.
I like the ups and downs of a cycle for the same reason you want nipple pain... it isn't exactly fun, but it sure is feminine.