This is a really rich discussion which mirrors much of the internal dialog and self analysis and criticism I have had. Not sure if this adds to the very insightful comments already made but nature feels more comfortable so I am more accepting of this theory. Nurture makes me feel uneasy as it makes me feel that but for others I wouldn't be this way. Separately my response to hrt was not in any way a placebo effect - intense dysphoria instantly disappeared, nothing, nada, gone which for me pointed to nature as the most likely explanation of my state.
Choice for me relates to how I choose to understand an experience. In general I select the paradigm which fits me best ie that with which I am most comfortable and that is normally the one which is kindest to myself and to others. Until the adopted paradigm is rejected either conclusively by society or I accept/adopt/evolve or embrace an alternate paradigm then this is my understanding. So in my case I am most comfortable with (intellectually and emotionally) with a nature explanation of my reality, I choose this explanation and within self defined or imposed boundaries I choose how I will deal with it, I think.
Of course if choice is an illusion and this has all been predestined then I am kidding myself. Not knowing how to prove which is true I again to choose choice as this possible illusion works best for me at this stage of my life/development/path/experience/ramble et al
