The only weird part about taking sertraline (Zoloft) and HRT for me is that it seems to make orgasms a bit more difficult to get to. Given the mechanism of a SSRI (Zoloft is actually a SMRI, if you wanna get picky) it makes a lot of sense. That said, I haven't noticed any issues with it so, *shrrrrugs* I guess it's kinda a 'whatever' situation.