Anyone have feedback about long term Sprio use?

[Satinjoy]

Results are in.  What I believe I can say is - Per the endo:  I stay on Spiro... on subligual E serums are still too low... and he switched me to straight up oral.  Which when I took it that way had an unexpected kick to it and no crash.  I liked it.


I am extremely healthy and haven't had a drink in 30 years so my liver can take it, but he told me he has been watching me like a hawk.  I turned my choices entirely into his care.

If my levels remain too low, he will take me into injections.

It actually was a great appt.  Somewhat disappointing, but on the plus side, and I think I can safely say this here, my testosterone level was 35.  I think thats perfect for me.  If it goes lower thats perfect too.

I did good.  I did not physician steer.  We had a great, informed conversation.  And I have heard by KayXo good things about when she switched from sublingual to oral anyway, from a previous thread.

Not bad for a cross addicted alcoholic, to stay with the rules.  I am happy about this in a big way.  My mind can lock down on this like crazy and now that I let go of the wheel its so much easier.

Enjoy.  I needed and enjoyed all of the help in this section of the forum on hormones.

[AnneB]

'really happy your appt went well.. and T level at 35??  OMG!  I'd KILL for that!  I'm still at high 200's!  But I begin my script-based HRT next week, so I hope I'll be along shortly!  =)   I'm in the US, and from what I understand Cyprotone isn't available here.  I guess I'll find out what's the standard soon enough.

Congrats, still! 

Paula

[KayXo]

You also must consider two things.

First, that Spiro weakly blocks androgens from binding to androgen receptors so that while T may be at 35, some of it is blocked by Spiro.
Second, if this is total T and your SHBG is quite high (usually from oral estradiol), then a significant part of that T is unavailable, not active, bound to SHBG.

So levels do not tell the whole picture.

One could even go further and mention that these are levels in the blood only, that in tissues, levels may be quite different and how much is metabolized, converted, etc in tissues may depend on several factors.

I think, in the end, your best bet is to watch for how your body responds and how you feel in general. This will give you a quite accurate indication of what's going on. 

[Jennygirl]

I think, in the end, your best bet is to watch for how your body responds and how you feel in general. This will give you a quite accurate indication of what's going on. 

Agreed 100%!

[Satinjoy]

One thing is for sure, It is really really nice not to have estrogen lows right now, crashing twice every day.  And Again many thanks!  I am greatly encouraged now.  Next year is going to be physically very interesting.

Feels a lot different.  More subtle.  Color reception remains up and boobs remain a tad sore so I know there are active E levels.  When it drops the perception of colors does too with me.

Thanks girls!  Next tests are in 6 weeks.

[KayXo]

I also noticed that colors were more vivid when I first started estrogen. And then lately, after I added progesterone and switched to injectables.