Spike in T? Please help.

[CGKxoxo]

I wanted to make a post because I have became concerned about something.

I started HRT 3 and half months ago on a small dosage and then a Zoladex implant every 3 months. This started off great, I noticed amazing results and I felt better in myself and actually felt like I was on the right track.

However, after 3 months - I was due my 2nd Zoladex injection (I had to have it a week earlier because I was going away), and then my dosage was upped slightly. And now I have noticed a spike in T - (erections coming easier, sexual thoughts,  facial hair growing faster, feeling angry etc.) and I have no idea why.  After my 1st implant of Zoladex I was prescribed Cyproterone to take for 2 weeks to suppress the spike in T which you get, so I did that and then after those 2 weeks I was fine. Body and facial hair had a significant change, no erections or sexual thoughts.

I was told after my 1st implant I wouldn't need Cyproterone again because you only need it in the 1st 2 weeks of your 1st implant... so I don't understand why I'm seeing a spike in T now. It's making me feel angry, confused and I feel like I've completely gone off track.

Can anybody help?
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[KayXo]

Could be the withdrawal symptoms from CPA as it is being eliminated from your body, there is less blockage at the androgen receptor level so more androgen (from adrenal glands) reaching receptors. It will probably be temporary. I'm sorry you have to go through this.

[CGKxoxo]

Could be the withdrawal symptoms from CPA as it is being eliminated from your body, there is less blockage at the androgen receptor level so more androgen (from adrenal glands) reaching receptors. It will probably be temporary. I'm sorry you have to go through this.

Thanks for replying. I don't really understand though? What's CPA and I didn't really understand the rest, haha. Could you explain in a simpler way? Hopefully it is temporary, my sexual thoughts and erections have stopped and it seems to be getting better though. Perhaps after my next implant of Zoladex I should ask if I can have Cyproterone to block any spike in T.

[KayXo]

CPA is cyproterone acetate. It blocks androgen from binding to receptors so if cyproterone is less in the body, androgen (testosterone) is able to bind more with receptors, thus increasing androgenic effects.

It's temporary though and I'm glad you're starting to feel better. I personally don't think you need to readd cyproterone but your doctor has the final word, as always.