Quote from: Hideyoshi on May 26, 2014, 04:07:58 PM
Estradiol is unlikely to cause liver disease, but the risk is still there.
I have personally never come across any evidence showing an association between the use of
bio-identical estrogen marketed under various brands and regulated (i.e. Estrace, Progynova, Elleste Solo, Estrofem, etc.) and liver complications. Genetic women have estradiol coursing through their bodies most of their lives and I have not heard of women having more liver complications than men. Perhaps, there is a risk but I've just never come across any mention of this in studies actually showing this to occur with a clear association to bio-identical (17-beta) estradiol.
Quote from: HideyoshiThere are risks with every medication that changes the chemistry of your body.
But some compounds are associated with more risks than others. Progesterone and estradiol, both regulated and marketed under different brand names, are exactly the same molecules that are found in our bodies and as such, in general, confer less risks than their analogs such as Premarin, Ethinyl Estradiol, medroxyprogesterone acetate, etc. These have been duly noted in studies.
Quote from: HideyoshiThe fact that there isn't any requirement for packaging information, regulation, etc for BHRT is the reason I wouldn't take BHRT. It's a form of alternative medicine. I am ashamed to admit I bought into the whole alternative medicine/organic/holistic deal in my late teens/super early twenties. I know the urge to believe the claims of those who promise little to no side effects with equal results, but the science just isn't there.
BHRT, as I mentioned above is sold under various brand names. Prometrium is bio-identical progesterone. Delestrogen, Vivelle, Estrace, Estrogel are all bio-identical estradiol. These ARE regulated and come in a package with leaflet and all. It is not alternative medicine. It is potent and works effectively. Most transwomen these days take bio-identical estradiol and more and more take bio-identical progesterone, most of the time, regulated and manufactured by large pharmaceutical companies and occasionally prepared by compounding pharmacies, some of which are reputable and are regulated as well to a certain extent. If they don't work, it's quite easy to detect...