Congrats. Be sure to drink plenty of plain water, when thirsty, on Spiro and eat as much salt as you crave, while limiting high potassium stuff and even diuretics. Best way to avoid complications, leg cramps, headaches, dehydration, dizziness, etc.
On estradiol, best to have injections weekly to avoid ups and downs. If you notice too much fluctuation, let your doctor know and ask if it can be taken more frequently. Good luck! A new beginning... 🙂