Estrogen Receptor deficency. A very rare condition in which the body has no or very few receptors in the body which makes it impossible for estrogen to bind to anything making it useless, therefor only circulating in the blodflow untill you discard it via our natural disposal facilites.
Another condition worth mentioning is EIS but then again, it's not that really commonly known even if it would mean mostly a no-go for MTF's and the same goes for AIS and FTM's. I'm suprised no one have heard of it yet. But I can imagen most who found out about it would "disappear" rather quickly... A sad story indeed, but some of us suffer from it and living with it is just...
ERD however seems to "progress" over the years, or at least in my case were it pretty much went zero during my early months on HRT.