Multiple forms of Estrodiol

[KayXo]

I'd be concerned about liver toxicity from the peaks, but then I have pre-existing conditions from ~2 years of pills

Injections bypass liver first pass effect so aren't quite the same as pills. Also, in pregnant women, levels peak up to 75,000 pg/ml.

[Rachelicious]

Injections bypass liver first pass effect so aren't quite the same as pills. Also, in pregnant women, levels peak up to 75,000 pg/ml.

First-pass =/= 0% that the liver must handle. Hormone levels during pregnancy are irrelevant. Safety advocates using the lowest effective dosage, therefore I see no benefit to levels fluctuating from high to low. Surely one is too high, and one is too low.

This lack of control over dosage is why I will not try pellets/inject. Women generally experience bad symptoms from lack of control over monthly hormone levels. I enjoy having far greater power over my hormonal status than women who do not require HRT.

[KayXo]

Women experience bad symptoms because their levels drop significantly but on injections, if done frequently enough, there is no such drop, levels remain quite high. I've not experienced bad symptoms. Some fluctuation could be beneficial in the sense that it could avoid desensitization of receptors to too constant levels.

Pellets deliver quite constant levels as compared to injections.