Certain things surrounding hormones don't just flip on or off by skipping weekend doses and will instead just reduce the impact, and you don't want to lose/diminish the benefits you are trying to gain. As the same time, there are effects will hormones that may rise/fall more quickly, so you can't necessarily up your dose the rest of the week to compensate.
Ask your doctor/endo, but you will need to give your reasons "why." Even if what you want to do is possible, there may be another approach that addresses your reasons better.
