I'd more likely attribute a loss of appetite to anxiety than HRT. If you lead a particularly stressful lifestyle you may need to go through special efforts just to keep anxiety away (ex. meditate.)
HRT did though sap a lot of my muscles from banishing testosterone. I loved it at the time since I was a bit too built, but it certainly is a lot harder to gain muscle than it used to be! My overall weight has settled over the past few yers to around ~20lbs less than before, which is probably consistent with overall weight ratios between male and female, especially considering I was more muscular before.