On 1 October I started on my estrogen and Spyro, there has been no physical changes as of yet, but I really didn't expect any this soon anyway. But the emotional and comforting effect has been overwhelming. I feel at peace, probably because the testosterone is reduced flowing through my body. It really is nice not having all the sexual urges and I always did hate waking up with one of those nasty spontaneous erections. A month into it now, I don't experience that at all, which I'm grateful. Really don't know if the piece and calmness is in my subconscious or on a molecular level, physically, things are changing to line up more how I've always felt I hope this answers your question. Good luck on your journey. A big hug from me to you.
Hugs,
Melissa Ann