Katiej- I am a retired physician. I was a nephrologist, or kidney doctor. However, because of the nature of the patients that were mine, I did quite a lot of primary care as well. I can assure you in this day of information sharing that common HRT protocols are readily available and explained in detail in the medical literature. For years I subscribed to "UptoDate" and every quarter, I got a CD with all new discoveries published in all medical subspecialties. I will also say, from your description, that if your primary is in a transgender clinic, that she should have the resources there to answer all of your questions both before and after starting standard HRT. Chances are that the endo may actually have less experience with the protocols than your primary. I know from my own practice that getting in to see specialists will be harder and harder as we move into medical care changes. It likely will not be uncommon for many of us to interface with a nurse practitioner or even physician's assistant for primary care in the future. I would like to qualify one circumstance, IF you have ever had a thyroid or parathyroid hormone issue or are a diabetic, then at least an early evaluation by an endo would be something I would suggest. As well, if you have been on any form of testosterone in the past, like me, then establishing levels and getting the correct dosing is critical and may best be done under the care of an endo. But, if it is a simple case of straight forward HRT with no qualifiers, I personally, would stick with the doc that knows you the best. Hope this helps, and is NOT a medical opinion, only experience from a transwoman who has been in the field. Hugs, Sheila Grace