All bodies are different... I've noticed muscle loss earlier this week and I've been on HRT around.. 3 weeks, mostly my legs. I was wearing a size large leggings, and they used to fit pretty tight and snug... now I have moved to size small...having to wear large again tonight because my small's are all needing to be washed, they feel really baggy :\
As far as weight... within the 3 weeks, I've lost roughly 27 pounds... thinking most of that is muscle mass as no changes really any where except for legs & arms have decreased in size, in general.
NOTE: I was jogging regularly until just about a week ago, and I stopped due to the cold weather (can't stand cold weather)... and my diet has been around 1000 calories a day, sometimes less. So now I pretty much sit in front of a computer most of the day... so possibly, with not exercising, the muscle is being eaten away more quickly with the T blockers.... ideas?