There are some activists, including some very well known names, who have put out the word that Title VII protects trans* people because of the Macy v. Holder decision. But the problem with that is courts are higher than the administrative agencies like the EEOC. This means that no court is require to comply with the EEOC decision. This decision illustrates the point. Trans* people (and lawyers for trans* people) should be aware of that and think twice about the cases we bring to the courts. Too many decisions like this and Macy v. Holder will no longer be good law.
That, by the way, is probably part of why the EEOC chose to file the two recent lawsuits that it did. If memory serves, the two recent trans* discrimination suits were filed in courts that fall under the sixth and eleventh circuits, both of which have already indicated their agreement with Macy v. Holder. So as a matter of good strategy, go to those courts first, get rulings that are supportive, then you go to other courts like the Fifth Circuit where there's more of a question and you have some prior rulings to cite.