@Releca
I'm sorry about having EDS. Have you genetically screened what type you have yet via bloodwork?
My 20 year old boyfriend (FtM) just finally got diagnosed with EDS (hyper-mobility), but has been on HRT (IM) with no undue side effects. Besides the body pains from EDS

. At least we know why none of the fibromyalgia medicines weren't working. Now i just need to get Him to see a specialist and start some physical therapy. Though the closest specialist is about 2.5-3hrs away from us in Chicago and he already sporadically needs a leg brace and/or cane to get around some days. It breaks my heart to see Him in that kind of pain to where I can't even touch Him lightly sometimes to show affection.
But as far as I know, there has been no additional risk to life from the HRT being conjoined with the EDS. Not too many cases to go by for this though since both EDS and TG are rare in the population. And the conjuncture of the two is probably like 1:1,000,000 or higher. Especially depending on the subcategory of EDS. As far as surgical complications, we will have to find out as that comes along. He plans to get top surgery (double anchor) within the next two years, when He can afford it. Currently He just binds for most public occasions. After that He plans to get a Phalloplasty when funds become available. (Luckily His insurance covers a good chunck of both procedures, unlike mine where i need to pay 100%).
Good luck with your progress

~Pixie