I'm on a full dose of spiro and a lowish dose of estradiol as I understand it (my endo emphasized that she likes to start very slowly to give the body time to adjust and develop slowly at first). With that, I noticed some clear physical effects within a week. Things then fell into a holding pattern until about a month, maybe a bit more, after starting, but some more changes are happening now.
Within the first week, and maybe just a couple days, my skin softened and became a lot more prone to dryness, especially on my cheeks/forehead. (I also had some dizziness, lots of peeing due to spiro, and a few other things I'd call "side effects," but I don't count those. They all went away after a week or two.)
After 4-5 weeks, I've had some obvious psychological effects (feeling moodier, both happier and sadder, and have had one very out-of-character instance of sobbing while reading a touching section of a book). I am also having increasingly frequent soreness in my nipples, which may be affecting more of my chest now. That started after 3-4 weeks with on-and-off instances, but the last 3 days now it has been pretty much always present and I think maybe it's getting more noticeable. No clear evidence of breast enlargement at all.
Also, my wings came in and I can almost fly. Giving that another week or two.
