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Doing some math

Started by Amy1988, April 01, 2015, 08:31:39 AM

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Amy1988

April 01, 2015, 08:31:39 AM
Ok so I read that the liver metabolizes about 30% of the pill form estradiol.  So if a person takes 2mg then by my calculations that would leave 1.4mg that survives the liver?
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KayXo

#1
April 01, 2015, 08:41:59 AM
Bio-availability from pills is typically, on average, 5% so that only 5% of the estradiol swallowed will make it to the blood. I can PM you the various sources that cite this.

From 2 mg, you get 0.1 mg estradiol, similar to the 0.1 mg patch.
I am not a medical doctor, nor a scientist - opinions expressed by me on the subject of HRT are merely based on my own review of some of the scientific literature over the last decade or so, on anecdotal evidence from women in various discussion forums that I have come across, and my personal experience

On HRT since early 2004
Post-op since late 2005
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Amy1988

#2
April 01, 2015, 09:04:29 AM
Quote from: Amy1988 on April 01, 2015, 08:31:39 AM
Ok so I read that the liver metabolizes about 30% of the pill form estradiol.  So if a person takes 2mg then by my calculations that would leave 1.4mg that survives the liver?

Please send PM
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ImagineKate

#3
April 01, 2015, 09:44:42 AM
I take it sublingually to avoid the liver pass.
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Amy1988

#4
April 01, 2015, 09:48:34 AM
Quote from: KayXo on April 01, 2015, 08:41:59 AM
Bio-availability from pills is typically, on average, 5% so that only 5% of the estradiol swallowed will make it to the blood. I can PM you the various sources that cite this.

From 2 mg, you get 0.1 mg estradiol, similar to the 0.1 mg patch.

What is the bioavailability of .6 mg estradiol gel?
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