Has there been any verified (studies) association between high dose injectable bio-identical estradiol (if that is what you were taking) and health risks? As far as I know, pregnant women can experience levels as high as 75,000 pg/ml that extremely high doses would still not be able to yield and pregnant women are not dying left and right, their DVT risk stands at 0.05-0.2%.
Premarin is another story because it is not native to the body, is taken orally and has been shown to significantly raise DVT risk, especially at higher doses.