For the longest of times I was a drug addict.
After accepting that perhaps transgender isn't so far off I haven't touched much drugs anymore.
And I had a thought once which basically accounted for:
what if you assume that you operate the same way as others? Then you blockade yourself with all its consequences: disease, psychosomatic symptoms, psychological problems, professional problems, conflicts in communication, relationship problems, addictions, a hole / one void in yourself. Because that what isn't seen nor heard, what is not allowed to come to life, expresses(manifests?) itself in an unhealthy manner !
Perhaps you don't call it dysphoria, per se but i've had a few issues being resolved after self-realization.
the combination of intensity and emotions. Until someone explains you that a person whom can't furfill their unique desires can end in loss of all desire to do anything at all

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