While I was in school, almost every project I did that left me with free rein ended up being about transgenders. As a result, I've (effectively I hope) educated a few classmates who previously could admit to not even knowing the word transgender until then. I know cisgender people will probably never get the concept, cause its waaaaay different from sexuality, but people like my aunts and uncles on my moms side, unfortunately the closer side, seem to think that if I'm just confused. They think that because I identify as lesbian atm, but I'm transitioning to male so I am in fact straight. They think it has everything to do with moving from Chicago and in a way they're right. I moved from there to an open-minded area, full of LGBT people an my best friend who seems to be fine with this, though I had to explain the difference between a strapon an packer lol.
I try getting the ones my age though. Older adults are stuck in their mindset, it's iffy if they'll ever get it. Teenagers and kids are still developing opinions and its always shifting, so those are ones I feel you talk to first. Gives you more time to get them to understand. But I'm giving my family until I'm 36 for them to understand. I came to terms with it when I was 17, but really started working on it when I turned 18 and had control. If they don't get it in 18 yrs like I did, its no longer my concern.