Not sure if this exactly correlates with topics that of transgender, so I had placed this here.

Anyways, about a year ago I was taking basic biology and genetics courses at community college, and through some research on my own accord, as well as my instructors and I having many rather intimate conversations on the whole of the subject of what determines the whole process of what determines gender.
So as there is an understanding of XX chromosomes equate to female, and XY equate to male. Which is only a very small part to the justification of how the body grows into the specific gender in the womb. I do know while, the sizes of the XX and XY chromosomes are different in stature as per the XX as the sex determination chromosomes will be at a relaxed state and thus lay almost flush together, while the XY chromosome balance arches the X to connect to the telomeres of the Y chromosome. As an example through just a comparison by typing letters into this whole bit, XX the space between both X's would correlate how they will link genetically, while as the representation of chromosomes size the XY, is really under the size difference that of Xy, and so the upper telomer of the X chromosome will need to curl to connect to the Y chromosome. This is all just the physicality of the chromosomes itself actually, and does not facilitate the growth or non growth of sexual organs or hormones.
But to the point of what actually compromises the whole properties of being male is a small gene that is generally located at the upper length of the Y chromosome, which the gene SR Y, is what gives us the ability to develop as a male, to produce the hormones needed for growth, for the body to start developing the male attributes such as the testes and penis.
Through my research I came across many articles, I don't remember them off the top of my head at the moment but could probably easily be looked up, which researchers had isolated the SR Y gene off of the Y chromosome, in mice. Results of an XY chromosomal mouse without the gene was an outer appearance of male, but without growth of any genitals. Needless to say deeper research carried out that mice which had an XX chromosomal but with the SR Y gene implanted, generally when the mouse had grown it was female in appearance, though also was more aggressive as the standpoint of male, as well as it's male genitals.
I also know of Turners syndrome which is represented as a chromosome XO, or X_, which is lacking the secondary X or Y chromosome, which develops as a female, but is not really in the standpoint of "healthy" which lots of different issues will arise and not really be able to live as a normal XX chromosome female.
As well as Klinefelters, either XXX, XXY, XXXY, or even through greater meiosis issues the forms of XYY, or XXYY,
Which all variances cause a lot of issues at birth as well as growing into the body determined by genetics.
I just totally nerded out.
Let's all climb aboard the choo choo train to happiness
Kateā„
Edit; oh yeah, forgot where I was going with this, but it puts me in a pattern of thoughts that maybe one day through looking in our own genome could we pinpoint a more precise justification on our transgendered state.