I don't really think it makes much of a difference. I was actually being administered a very heavy dose of T for years before starting MtF HRT. The past 6 months, I've lost over 65 pounds and it's been pretty consistent at around 10-11 pounds a month going from 225 down to 158. The first 2 months were while I was on T, the next month I wasn't on any hormones, and the past 3 months I've been on spiro and E. When I first started MtF HRT, I was more hungry for a few weeks, but I simply ate more fruits and veggies and less meat and the extra hunger went away. For myself, it was the other medications (thyroid and BP) that I was taking that hampered my weight loss for so many years. Now that I am off those, weight loss has been pretty easy.