Hi Stevie
First off, I think you have nothing to worry about. Despite whatever political veneer people slap on top, I believe that most people (politicians excluded) are basically reasonably decent, and have a live-and-let-live attitude.
Part of the issue with work colleagues, I must be frank, is how integrated you are, and how passable you are. But it's only part of the issue. My experience has been excellent, both in terms of colleagues who lived the change with me and those who saw me afterwards. I was incredibly lucky to pass straight away, so, apart from the occasional wagging tongue, there have been no incidents. The only issue, which you've already identified, is the change in gender dynamics, which has been subtle but evident. I do have to compensate a little by being a little more vocal, but it's not a major issue.
On your question, you have the dual advantage of knowing this man, and you are already established in your company. I wouldn't expect any issues. This said, if I was in your shoes, I'd gently establish the ground rules, including discretion around your colleagues and other points. Nothing militant, just weave it into a conversation

Hugs
Julia