Quote from: Cindy on December 29, 2015, 02:06:31 AM
Progynoa is oestrodiol valerate. It is not bioidentical.
Proynova is indeed estradiol valerate. IT IS bio-identical as it converted to 17 beta estradiol in the blood and not active until it is de-esterified or cleaved.
http://www.ncbi.nlm.nih.gov/pubmed/7169965"After oral or parenteral administration, oestradiol valerate, the synthesis compound contained in various commercially available preparations, is completely converted into the natural substances 17 beta-oestradiol and valeric acid. The 17 beta-oestradiol produced on cleavage of the ester behaves in the organism like the endogenous steroid hormone. Oestradiol valerate and 17 beta-oestradiol are virtually dose-equivalent. No differences in the spectrum of action of the oestrogen and its ester have been found either in animal experiments or man. The pharmacokinetic behaviour and the biotransformation of the 17 beta-oestradiol originating from oestradiol valerate are no different from those of natural 17 beta-oestradiol."
I personally take very high doses of estradiol intramuscularly (levels ranging from 1,000-4,000 pg/ml), a moderate-high dose of oral progesterone and all my blood tests have come back clean, including liver panel, clotting factors, lipids, glucose/insulin, etc. I have three doctors supervising me, an endocrinologist from Cambridge who's treated several hundred transpatients for many decades, a woman who wrote a book on female hormones and my family doctor and all approve.
My diet: HIGH fat (mostly animal) like bacon, eggs, butter, red meat, coconut oil, macadamias, low to medium carb, some protein, mostly animal. Lipids are great with HDL quite high and cholesterol:HDL perfectly fine.
Studies have shown that when bio-identical estradiol is taken, clotting is less affected and that especially non-orally, the effect is negligible, even at high levels. It was even claimed that estradiol, non-orally, protects against the occurrence of thrombosis.
