Prometrium has been a mixed bag for me. It's really hard to separate what P has specifically done vs. just E, but I'll attempt an answer anyway.
The physical effects:
1. My boobs rounded out and lost that "traffic cone" look. My areolas have gotten larger and look very feminine now.
2. My butt has grown and now I have some hips.
3. With the boob and butt growth has also come gut growth - I'm really hungry during those 12 days each month! Strangely enough, I still weigh about the same as before transition - the weight has moved to typical female locations..
The mental effects:
1. P was a wild mental roller coaster when I started it. I was all over the map, from weeping to anger to moodiness, sometimes all within an hour. I stayed the course and after a year that has settled down.
2. Men treat me as a female. That includes misogyny and goofy, weird behaviors around me. For example, today I was at CVS to drop off a prescription and an older guy that had been sitting on some chairs against the wall observing me for awhile got up, walked by me, stopped, said "I'll bet i'm as tall as you are before you put those heels on", and then walked away but not before bumping shoulders with me. Weird? Yeah. Don't know what that was all about. Maybe he liked me

3. Passive? I have always been passive, living as a beta male before transition. Now I act like any other woman and am deferential more than I probably should be. Women use soft skills rather than using force to get what they want - that can include being deferential while batting your eyelashes, letting men think that they solved the issue at hand when you really solved it. Learn to use your femininity - it's power wrapped in a velvet glove. Women really run the world