One of my favorite TG characters will always be Wanda from a game of you. The collected story from Sandman
Yes she has the moon fall on her, but i identify with the way she is scared
and hope that I will half as beautiful as her at the end of her journey.
and there is another Vertigo title, wher there have a meta human TG who has the power to melt objest. Sigh I read it once.
In genneral Vertigo characters has positive images of everyone, as well the negitive just like real life, weher you can see how something affects but does not becoem a johny one note.
There was a story in " The Dreaming" where this woman born a male , dies comes back as a woman, and then becomes a night mare. Her struggle with who she is defines what she becomes and her redempton is interesting.