I've always been alone, more or less. Yeah, I had some friends back in the day. But, I never really felt like we had a true connection, other than the fact that we got intoxicated together. They ditched me once I came out. Oh well. Good riddance.
Even though my relationship with my family is basically okay, my relationship with my father certainly went downhill once I transitioned. Sure, we still see each other since he and my mother live together (even though they have been divorced for years). But, we barely speak to each other. We just don't have much to say to each other anymore. Oh, well. That's just the way it turned out. It doesn't matter.
As far as being alone is concerned: Honestly, that would have occurred no matter what my gender situation would have been. Cis-male, Cis-female, Transchick, Transguy. It would have made no difference at all. I always knew that I would be alone. 95% of the time, I don't care about it. The remaining 5%? I just deal with it and get over it. The truth is that I could never live with anyone anyway. I'm pretty difficult to live with and set in my ways at this point. So, I don't need to deal with someone else complaining about how I do things. That's not even considering bringing gender into the mix, either.