I'm on Spironolactone myself. My physician told me that I could take it at any time of the day, but kind of gave me a hint so far as the consequences of each time. It has two very prominent negative effects:
- Tired/fatigued
- Need to pee a lot
So if you take it in the morning, you'll more likely notice that you are very tired. If you take it later at night, then you might notice that you need to make a lot of trips to the restroom (it'll disrupt or discomfort you as you try to sleep). Of course: Always consult with your physician. I am not a medical expert.
Personally, I like to take it at night, and taking it around 6 pm makes it most manageable for myself.