Quote from: rikki88 on February 27, 2016, 05:26:41 PM
My Spiro was upped at the beginning of the month. My soreness went away and just recently my random erections came back. No morning ones but yea.... Now my nipples are super sensitive and sore all the time.
About Spiro (and cyproterone acetate), two things that are not so well-known:
1) they bind to androgen receptors, thereby blocking T and DHT BUT do have slight androgenic activity, although much weaker than testosterone or DHT. This is why in an environment where T and DHT are already low, administering either could have undesirable effects or taking too high a dose.
2) both these "anti-androgens", not pure "anti-androgens" (closest being bicalutamide), also increase hepatic enzyme CYP3A4 responsible for metabolizing oral estradiol so they could well reduce concentrations of E2 in the blood if your E is taken orally.
Usually, they will be more beneficial than not but there might be situations where dose is too high or when taken post-op, that they might actually do more harm than good. Something to consider.