Bicalutamide (Casodex), taken alone, is less likely to affect spermatogenesis and shrink testicles/penis because it actually increases testicular production of androgens (due to blocking negative feedback at pituitary gland and hypothalamus) while strongly blocking effects of androgens at receptors with the net result of less androgen affecting your body and increased estradiol feminizing you. But, it is unlikely full feminization will be achieved on just this anti-androgen.