Quote from: Adchop on March 31, 2016, 10:40:56 AM
Also, is there any place in particular that is best to wear them?
Menopause. 2000 Sep-Oct;7(5):364-9. (with Climara, 7 day patch)
"After application on the buttock, mean peak plasma concentration (Cmax) was 125.1% and mean relative bioavailability (AUC(0-168)) was 117.2% of that from the abdomen site."
"In summary, the buttocks seem to be an acceptable site for the application for this once-weekly 17-beta estradiol transdermal delivery system. Because the extent of absorption was significantly more for buttock than for abdomen application, this application site may provide an advantage in women who experience menopausal symptoms at the end of the week."
J Clin Pharmacol. 1996 Nov;36(11):998-1005. (with Fempatch, 7 day patch)
"Mean serum estradiol concentrations were higher after application to the buttocks than after application to the abdomen (19 and 15 pg/mL above baseline, respectively), making the buttocks the preferred site for TDS application."
The difference between both sites of applications appears to be small though.